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Some people taking metformin develop a serious condition called lactic acidosis.

While these drugs alone do not cause hypoglycemia, special instructions should be given to patients who use them in combination with sulfonylureas or insulin.

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Treatment with Metaglip lowered the 3-hour postprandial glucose AUC, compared to baseline, to a significantly greater extent than did the glipizide and the metformin therapies.

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Metformin is known to be substantially excreted by the kidney and because the risk of serious adverse reactions to the drug is greater in patients with impaired renal function, metformin should only be used in patients with normal renal function (see CONTRAINDICATIONS, WARNINGS, and CLINICAL PHARMACOLOGY: Pharmacokinetics).

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These lists are not complete and there are many other medicines that can increase or decrease the effects of glipizide and metformin on lowering your blood sugar.

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If patients have not responded to four weeks of the maximum dose of metformin monotherapy, consideration should be given to gradual addition of an oral sulfonylurea while continuing metformin at the maximum dose, even if prior primary or secondary failure to a sulfonylurea has occurred.

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